Variants in common diseases
نویسندگان
چکیده
منابع مشابه
Emergency Management of Common Diseases in Children
Acute respiratory infections, diarrhea and fever are very common in children below the age of five years. All children suffer from these illnesses several times each year. However, during natural disasters like floods children are even more vulnerable to these diseases and death. Pneumonia, diarrhea, measles and malaria, and associated malnutrition, are responsible for over 60% deaths in childr...
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abstract mutations have been described in all of the four open reading frames of the hepatitis b virus (hbv), however, from a clinical perspective the surface escape mutant is the most troublesome. hepatitis b surface antigen (hbsag) variants may impair diagnosis, or allow the virus to escape vaccine-induced immunity or passive immunoglobulin therapy. hbv mutants with amino acid substitutions, ...
متن کاملRare and low-frequency variants in human common diseases and other complex traits.
In humans, most of the genetic variation is rare and often population-specific. Whereas the role of rare genetic variants in familial monogenic diseases is firmly established, we are only now starting to explore the contribution of this class of genetic variation to human common diseases and other complex traits. Such large-scale experiments are possible due to the development of next-generatio...
متن کاملSBERIA: set-based gene-environment interaction test for rare and common variants in complex diseases.
Identification of gene-environment interaction (G × E) is important in understanding the etiology of complex diseases. However, partially due to the lack of power, there have been very few replicated G × E findings compared to the success in marginal association studies. The existing G × E testing methods mainly focus on improving the power for individual markers. In this paper, we took a diffe...
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ژورنال
عنوان ژورنال: Nature
سال: 2007
ISSN: 0028-0836,1476-4687
DOI: 10.1038/nature05568